One of my videos on YouTube shows people how to make their own suppositories. As you may know, we sell the kits to make your own suppositories for healing internal hemorrhoids, so I also made this video to give people an easy-to-follow tutorial. However, one of the viewers on my channel asked whether she could put Valium in the suppositories to relax rectal spasm.

I had never thought about that, although I do have an eBook on Natural Treatments for Rectal Spasm, so her question set my brain humming…

And I started thinking about what substances could be put into a suppository to relax the rectum (muscle tissue), which then led to me thinking about proctitis or localized inflammation…

I have extremely effective suppositories for anal or rectal fissures – FissureHeal – but they are not muscle relaxants, nor do they specifically target inflammation. But you know what does?


Keep in mind that Cannabis sativa contains over 421 different chemical compounds, including 60 cannabinoids. But for the purpose of this article, we’ll just talk about the two most commonly studied components: THC and CBD.

So then I wondered, how does Cannabis sativa behave when administered rectally? Well there’s been a ton of research done on this powerful herb – which the medical literature refers to as a drug and of course Big Pharma is testing synthetic versions they can patent – and I found a nice overview on PubMed comparing all the different application and absorption rates of inhaled, oral, rectal, transdermal, intravenous, etc. And guess what?

Rectal absorption and utilization of cannabis is twice as effective as oral:

“Rectal administration of 2.5−5 mg of THC produced maximum plasma concentrations of 1.1−4.1 ng/ml within 2−8 h. The bioavailability of the rectal route was approximately twice that of the oral route due to higher absorption and lower first-pass metabolism.”

However, since THC is also responsible for a lot of the mental/emotional and undesirable cognitive effects of marijuana, you may want to use CBD instead. The good news is that CBD is also anti-spasmodic and anti-inflammatory:

“Cannabidiol (CBD) is a natural, non-psychoactive constituent of Cannabis sativa, but possesses pharmacological activity, which is explored for therapeutic applications. CBD has been reported to be neuroprotective, analgesic, sedating, anti-emetic, anti-spasmodic, and anti-inflammatory. In addition, it has been reported that CBD blocks anxiety produced by THC, and may be useful in the treatment of autoimmune diseases. CBD also has been reported to decrease some of the side effects of THC. These potential therapeutic applications alone warrant investigation of CBD pharmacokinetics. Further, the controversy over whether CBD alters the pharmacokinetics of THC in a clinically significant manner needs to be resolved.”

Step-by-Step Instructions

Unfortunately I cannot guide you in which brand of CBD to use, nor how much to put in each suppository. But I did find a really good article on How To Make Cannabis Suppositories you can use as a guide. I like this article because it gives you detailed instructions for 3 different strengths/dosages.

I also found this rectal cannabis suppository product you can purchase and each suppository contains 50 g of CBD oil – it doesn’t tell you the strength/concentration of CBD oil used, but at least it gives you a number to start experimenting with – or just buy it from them! They also give you a very useful tip regarding how far to insert the suppository to get maximum absorption:

“But don’t get carried away and push it too far in because if the suppository gets as high as the superior rectal vein, a proportion of the CBD will be metabolised by the liver and lost, whereas if it is absorbed by the lower two – the inferior and middle rectal vein – they don’t pass through the liver and maximum CBD is absorbed.”

So basically, you only push the suppository in about 2.5-4 cm – just past the first anal sphincter muscle.

What I can help you out with is organic cocoa butter to use as your suppository base and my video that shows you how to make even super-thin suppositories in case your anus/rectum is constricted or wounded:

TIP: If you suffer from strong menstrual cramps, these same suppositories can be inserted in the vagina – push them high up against the cervix and the same anti-spasmodic effect will relax the muscles of the uterus. HOWEVER, if using vaginally, then I would use coconut oil as the base (place in the fridge to harden), rather than cocoa butter. Coconut oil is anti-fungal and absorbs quickly. Cocoa butter would be a bit too moisturizing for vaginal tissue (I would think) and thus may lead to itchiness.

Cannabis For Crohn’s?

For those of you who are interested in using cannabis to treat your Crohn’s symptoms, this is one of the best articles I’ve read on the topic. Sorry I can’t give you any ideas/advice as I personally am not drawn to this therapy – and while I was healing myself it was not available anyway! But this article is a good place to start.

Cannabis Suppositories for Rectal Inflammation and Spasm

35 thoughts on “Cannabis Suppositories for Rectal Inflammation and Spasm

  • Hi Jini:
    I started drinking your shakes many years ago when you were pregnant with your youngest. I live in Vancouver and actually spoke to your mom and you on the phone a long time ago. I have spoken to Iain as well several years ago.
    I had surgery for Chron’s about 18 years ago and unfortunately I hadn’t discovered your shakes until after that. However, I did drink your shakes over all these years when I went through various flare ups etc. I went through at least a 2 or 3 year flare up several years ago and only drank your shakes as well as some of the supplements you offer. As did my friend who also has Crohn’s.
    I have been in remission for a few years and I am writing today because I have just read your article on the cannabis suppositories.
    I was thrilled that you wrote this. I can tell you and anyone who wants to know that I started taking cannabis oil when I was in the last year of that 2 or 3 year flare up. I took it from a syringe and put a bit on a cracker and took it by mouth. However, it did give the psychoactive effect which I didn’t like. Eventually, I discovered the cannabis oil in different dosages by capsule form. I have a person that I buy it from who grows it organically and lives not far from Vancouver, where I live. I am convinced that between your shakes and the cannabis capsules, it put me into remission within a few months and without the psychoactive effects. I can’t say enough to support this. If you need any more information or anyone else wants to know anything that I can help share….feel free to contact me.
    Thank you for all you give!

    1. Hi Yvonne, My 15 yr old daughter got diagnosed with crohns 2 yrs ago. She was only on pentasa because she had no bad symptoms. She was just losing weight and low in iron. Colonoscopy showed inflammation in bottom of small intestine. Pentasa did not work for her. She just finished a bad flare up in hospital. Dr wants to put her on humira. I am extremely reluctant and would like to try cannibas oil. Just concerned about the CBD/THC combo. Don’t want side effects from THC but keep reading there is more success with THC and crohns. Do you think the suppositories are more effective than the oil?

      1. Hi
        No question about it, the suppositories have wayyyy less of the psychoactive effect (THC). My niece who is now 17 has been on Humira for several years and has been reluctant to try the cannabis oil but finally now with all the success stories she is going to try the oil via suppository method.
        I can’t recommend this enough as opposed to the Humira….for young people especially, there are SO many side effects.
        I would be happy to speak with you about it if you would like.
        All the best, Yvonne

      2. Just to clarify…..the suppositories that I am speaking about contain both THC and CBD and from my experience if one has Chron’s Disease, you need the THC. You just don’t get the psychoactive effect if you deliver it into your body by way of suppository. It might not even make one tired but that would be the only effect if any.

  • I actually suffer from rectal spasms and the doctor of course gave me nothing that helped. But did I miss where to get the CBD to use in suppositories? This stuff is illegal as far as I know.

    1. Hello Cheryl,

      CBD is now legal to purchase in all US states without a prescription. It is from hemp plant and does not contain the high amounts of THC that Marijuana does. Several local and online health stores are now carrying it, so you could either research online or call your local stores to see if they are carrying it. Please let us know if we can help with anything else.

      Kind Regards,
      Customer Care

    2. Cheryl’ I’m suffering from rectal spams’ for two years’ I can’t sleep and it’s destroying my life. I haven’t worked in almost two years. Have you tried the CBD suppositories & did they help you. If anyone can help me PLEASE DO’
      Thank you

  • Hi Yvonne – yes I remember you and SO glad you’ve found a combination that is so effective for you! There is actually a LOT of data/trials now available on using Cannabis for all kinds of illnesses, including Crohn’s. And yes, if you can use only CBD that is definitely preferable to get the bodily benefits without the mental effects.

    Thanks for your generous offer of support to others and if anyone wants to reach you, they can either post here, or contact us and we can pass on your email. 🙂

    1. Hello Jini/ listen to your gut team,

      Thank you deeply for the work and information you share. I have made cannabis suppositories & experienced great release using them. Currently I am having a flare up and not sure whether or not to do one, as I am having a lot of gas, hard to pass diarhea, and my bowl track doesnt seem clear. It feels like the suppository could soothe and help me release this build up that wants to come out, but I also don’t want to push the toxins further in….your opinion would be greatly appreciated. J

  • I had been suffering for nearly a year with anal fissures. First I was misdiagnosed by 2 doctors and finally, when I got to the surgeon, I had a surgery as well as put myself on a radical diet. At first after the surgery, I was not healing. I started doing more research and came across Listen to Your Gut, I was hopeful. I am an herbalist and decided to make them myself at home. Much to my surprise, when I could not find a ‘recipe’ with amounts, I messaged through fb and got a response immediately on ingredient amounts. I also work with Cannabis medicine and have access to lots of different kinds. I decided to add some grass fed cannabis butter that I had made to the suppository recipe. I had another surgery scheduled, and today, 3 weeks later, I cancelled it. I attribute the bulk of my healing, expedited, from these suppositories. I have not done the research yet, but it makes sense from what I do know that the CBD would have a similar effect on smooth muscle spasms as it would other epilepsy. I can’t believe I am not in pain 10 hours a day from spasms. Truly amazing. Thank you so much for sharing your healing knowledge. You are an angel.

    1. How are you doing now after the first surgery and the suppositories? Do you feel that you have completely healed? I have the same fissure/spasm and have been trying to avoid surgery for over one year. Trying everything under the sun to heal naturally. I have not yet tried the cdb suppositories but I will.

      Thanks for your input! Robyn

    2. Hi cecilia, so very glad to hear your input! My story is the exact same! Identical ! Only I still haven’t found a cure… could you please please help me with more details on what your exact methods and ingredients are and what type of cannibis oil etc! I have been suffering for so long and I truly cannot bare anymore pain 😞. My email is I would genuinely be so very very grateful if you contacted me and I will pay you for any help or advice you can give me. Thanks!

  • Hi Jini:)

    My name is jonas, im from denmark, and i just purchased your book, and it all sounds very interesting. I have proctitis, and i do you think that the suppositories from will help with the infection/ inflammation? Also if you have any other guidelines that isnt in your book, LTYG, i would really appreciate it:)

    Much love, jonas

    1. Hi Jonas,

      Jini has not personally used those suppositories nor can we comment on their efficacy with respect to your condition as we are not medical professionals and unqualified to do so but we’d love to hear your feedback if you decide to try them out. Also, make sure to check out Jini’s symptom page about proctitis if you haven’t already:

      Kind regards,
      Customer Care

      1. Ok:) thank you for the answer justin!
        I have checked it out, and i am doing the stuff that she recommends:)
        A problem is that after i started on the diet(s), its like im experiencing more gas and/ or bloating than usual, and my stool is also more liquidy and infrequent than usual. Is that normal when you change your diet that radically?


        1. Hi Jonas,

          It’s common for bowel movements to change as the body acclimates to a different diet and gas/bloating is also common as a result of a die off effect, especially if you’re using wild oregano oil and probiotics. Usually these things normalize after 1-2 weeks. We wish you all the best and look forward to hearing how it works out for you!

          Kind regards,
          Customer Care

  • Hi, Jini!

    So, as you probably remember, I’ve been following your Rectal StrictureHeal for some time now (a very short, but long-standing ring of scar tissue, while not severe, has taken awhile to get rid of), and while it appears to have worked like a charm (I’ve felt up in there myself, and all I feel is smooth, healthy tissue), I still have trouble with painful rectal spasming. Meditation for 20 to 30 minutes a day, as well as your Guided Meditations and self body work, have been extremely helpful, but I’m wondering now, after reading this post, if CBD is the puzzle piece that’s been missing. I’d be willing to try this, so thank you for sharing! I’ll be researching local and online stores for CBD oil this weekend.

    Stay awesome,


    1. Hello Brittanee,

      That is great to hear the Rectal StrictureHeal has helped you heal your scar tissue. We would love to hear how the CBD works out for you after trying it for the rectal spasms. Continue the great work and we hope your healing continues to go great.

      Kind Regards,
      Customer Care

  • I just wan to say….Thank You for this invaluable, very informative, very helpful web site! I had not been able to find any alternatives to surgery until I came upon this . I have partial rectal prolapse. I had previous surgery in 2011 for total relapse, which did not succeed (I learned a couple years later.) As a result, I have suffered intensely, with chronic constipation, excruciating pain and pressure due to anal stenosis/strictures- I just learned about through this site, unpredictable bowel movements, along with incontinence (both bladder & poo,) unbearable inflammation and swelling, and extremely raw and irritated rectum. I also have rectal spasms, which I have no control over and was forced to terminate employment last fall because of all these impossible symptoms. As a result, I have taken early retirement which barely supplements my husband’s monthly disability check. I have missed out on so much life with family, friends, and just being able to function normally as a person. Please bear with me, I know I am vomiting all over you, but you are the first place I have found that really understands; it’s not like you can talk about this with just anybody; this has been going on so long, I feel like it defines me. Thank you for listening, and again…thank you for this answer to my prayers…God Bless You!

  • Any advise about whether natural suppositories will temporarily alleviate discomforts of rectal polyps??

    1. Hello Millie,

      We do not have any experience on using suppositories for rectal polyps. If you do decide to try these or another kind for it we would love to hear how they work out for you.

      Kind Regards,
      Customer Care

  • We’re now making our own CBD/THC suppositories to mitigate the effects of a lemon size possibly malignant polyp in the rectum. Along with other supplements and inflammation reducing diet, they seem to be helping.

    1. Very interesting, Millie! Thank you for sharing. We’d love to hear how that works out for you and wish you all the best.

      Kind Regards,
      Customer Care

  • I fell on my tailbone years ago and have severe tailbone pain in addition to rectal pain. Do you think rectal CBD suppositions from Endoca will help?

  • Heres a challenge for your top notch team, I have successfully used the stricture protocol it worked wonders. I used 30% for 4 months administering at night. So heres the kicker, Ive had a rectal prolapse for about a year and a half, Ive only seen it a handful of times once I learned how to place my hands to prevent it from emerging and the squatty potty. I do have a considerable amount of pain when I have a BM but its located closer to the anal opening so my guess its fissures. (Ive had hemorrhoid problems since I was 15) and the fissure heal is a GREAT product but I think Im prone to them coming back. My question…with the success of these products I cant predict how many BMs I have a day(plus the pain involved). It rules my Day, Im 66 a Personal Trainer and Bodybuilder my diet is spot on and I like the same foods almost every day, so with pretty much the same foods and caloric intake daily why would I have 2 movements in the morning within 20 minutes of each other? Also why on some days do I have 2 and other days 6…REALLY?? the volume can change also and remember this is with the same amount of food. I use flax meal in the morning on oatmeal and a spoon of psyllium powder in water late afternoon to keep stool soft.

    1. Hi ken,

      Thank you for reaching out! It is very hard to say what may be going on, as we do not know your full health history, etc. But please check Jini’s Wild Oregano Oil Protocol,as your bowel issues may be caused by Candida overgrowth, or bad bacteria. Try also this stool bulking agent using 1 tbsp. sprouted flax and chia powder (available locally and online at various sites; you may have to purchase the two powders separately)along with 1/2 tsp. bentonite clay to keep your stools soft and spongy, stimulating peristalsis and making them easier to pass. Take Natren brand probiotics whilst consuming the shakes, this can often reduce the urgency and liquidity of bowel movements. If you are constipated, then you can take the Natren Healthy Trinity capsules. But if you are having frequent bowel movements, then you need to use the Natren powders.

      If you tend to get attacks of cramping where you have to run for the toilet then a Colonic Massage will be a big help to you. You can give yourself this colonic massage while sitting on the toilet to help reduce frequent loose bowel movements:

      Self-Administered Colonic Massage – Constipation, Diarrhea, Gas, Bloating

      Please let me know if you have any additional questions or concerns.

      Kind Regards,
      Cris B
      Customer Care

  • Hi- the link at the end of the article, cannabis for crohn’s is broken. “404 Not Found”
    Just an FYI.

    1. Hello Tara, thanks for the heads up! Try these links below:

      Keep in mind that the links above isn’t related to any research by Jini so take it with a grain of salt. Jini always recommends that you listen to your gut and to consult a professional if you are unsure.

      Kind Regards,
      Cris B
      Customer care

  • My husband suffers from anal fissures because the stool he passes is acidic and burns / cuts his skin. Do you have advice or articles that can help him?

    1. Hi Katie,

      A good place to start if you want to learn more about treating Anal Fissures naturally is at Jini’s symptom section at the link below:

      Jini provided few easy remedies you can try first to heal anal fissure. If they don’t work well enough, then you’ll likely need Jini’s custom-made FissureHeal suppositories. This suppositories contain comfrey – which is a fantastic wound healer. Therefore, they heal anal or rectal fissures amazingly quickly.

      Please let me know if you have any additional questions or concerns.

      Kind Regards,
      Cris B
      Customer Care

    2. The best thing I have found is slippery elm bark pills, buy anywhere, even at Superstore in the health food part. It coats the intestines and no more nasty, acidic burning and no more fissures.

  • I am very glad to see cannabis mentioned here. This amazingly healing herb is God’s gift to humanity. Back in the 1920’s, when the drugs of western medicine were gaining a foothold, the corporate greed of big pharma and the wealthy and powerful in government decided to do an anti-smear campaign on cannabis, as they knew how effective it was, yet could not patent it, so they told lies and smeared it, made the movie “Reefer Madness”, also steeped in lies and racism, and then deemed it illegal, so people could not get the healing herb. No end to the evil of these places trying to make money.

    I read a few years back about how effective cannabis is for Crohn’s. I then got myself a medicinal prescription (thank the Lord it is now legal in Canada, though old stigmas, based on lies, die hard).

    I am in the middle of a nasty flare, having been in remission for 7-10 years, 7 of which was drug-free. I believe my flare was caused by erythritol, which I was using in my keto diet. I should only ever use honey. It is good to the gut.

    The cannabis (vaped or oil) is so completely effective at taking care of the pain – the real stuff with the THC:CBD ratio, not the CBD hemp stuff. The high TCH to low CBD is the best for pain. Don’t be afraid of the high. That’s where the healing is for Crohn’s. Just go to sleep on that cloud it provides and feel good for once. Side effects? Sure, giggles and munchies. Even improves your attitude too and gives you hope. I went from feeling miserable to a wee dance and even eating some food.

    I just returned from the hospital and now know 100% that they have nothing to offer me. I had to take the steroids but DC’d the antibiotics as they were giving that poison on my empty stomach and it was burning a hole in my gut. Doctor’s call you non-compliant but it’s your body and you know what you need. If something goes down like poison, that’s what it is. So much better with the oregano oil. I asked to be discharged home from the breakfast of sugar – jello, ginger ale, apple juice, tea, sugar, to my good food, soft bed, fresh air, garden, and sweet hubby and pup. That’s
    where the healing is.

    I just wanted to encourage anyone about cannabis for their IBD. I had some morphine in the hospital and it’s not nearly as effective or pleasant. Cannabis is also non-addictive. What’s not to love? The best place to learn the truth of it is at green flower media. Very helpful/truthful information by educated folks.

    1. Hi Heather,

      Thank you for sharing with us your success using cannabis as a means of combating pain. Have you ever used it in the form of a suppository for vaginal or rectal pain?

      Savannah – LTYG

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